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Sources: Clinical Nutrition ESPEN (2020)
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Furthermore, exercise increases reactive oxygen species (ROS) levels through various mechanisms and then triggers the activation of Nrf2 9,10 .MOTS-c is an open reading frame peptide encoded by a mitochondrial 12 s rRNA gene 11 , which mainly targets muscle tissue, significantly enhances insulin sensitivity, and improves glucose utilization 12,13
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