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So knowing that, its not perhaps surprising that there were cardiovascular benefits that were potentially even outside of the degree of weight loss that we see, or the degree of glycemic control that we see, Coviello explained

Gastroenterology 1979

Thats not failure

Diet and exercise must be considered as the first line of treatment, however if they fail to correct metabolic signalling, IGF-1 therapy seems to be promising at metabolic harmonisation