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Of the affected genes, 59% were upregulated (made more active) and 41% were downregulated (made less active)

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These variables meaningfully influence both efficacy and safety, including cardiovascular risk, thrombotic events, and metabolic response

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Yamamoto H, Lee CE, Marcus JN, Williams TD, Overton JM, Lopez ME, Hollenberg AN, Baggio L, Saper CB, Drucker DJ, Elmquist JK