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Although there is no consensus regarding whether GLP-1RA can increase the risk of thyroid cancer, some countries have relevant regulations to prohibit the use of GLP-1RA in people at high risk of medullary thyroid cancer and those who have already had medullary thyroid cancer

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This is attributed to compounds like hericenones and erinacines

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After pre-conditioning in the presence or absence of 50 nM Exendin-4 for additional 18 hours, culture medium was changed to serum-free DMEM containing 1 mM sodium pyruvate, without glucose and sodium bicarbonate