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Translating rodent pharmacology to human outcomes involves substantial unknowns, including bioavailability differences, effective dosing, and long-term safety

Although cysteine can be derived from the catabolism of extracellular glutathione, protein catabolism or de novo synthesis from methionine, 12,13,14 the major source of cellular cysteine is the dietary intake of cystine, the oxidised form of cysteine

doi: 10.1124/jpet.114.218735

Fragmentation pathways may involve cleavage at amide bonds, producing characteristic fragment ions corresponding to partial backbone structures

Luo M, Zheng L-W, Wang Y-S, Huang J-C, Yang Z-Q, Yue Z-P, et al