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Quick Takeaways Tesamorelin has robust clinical evidence for reducing visceral fat (15-17.5%), increasing lean mass (1.42 kg), and improving metabolic markers in human trials Ipamorelin selectively releases growth hormone without affecting cortisol or prolactin, making it the cleanest GHRP available Combining a GHRH with a GHRP creates synergistic GH pulsatility that mimics and amplifies your bodys natural growth hormone patterns My recommended protocol: Tesamorelin 1mg + Ipamorelin 100mcg, injected AM/PM, 5 days on/2 days off, 8 weeks on/8 weeks off What This Peptide Combination Actually Is Tesamorelin and Ipamorelin target different receptors in the growth hormone regulation system, which is precisely why they work so well together

For someone on a GLP-1 medication who is trying to preserve lean mass while still getting quality cardio in, a rowing machine is one of the most efficient tools available

These peptides mimic the action of insulin-like growth factor, which plays a crucial role in anabolic muscle cell signaling

Broader evidence supports this preventive approach

Osteocalcin activates lipophagy via the ADPN-AMPK/PPAR-mTOR signaling pathway in chicken embryonic hepatocyte