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Systematic integration of quantitative and qualitative information into the framework of an adverse outcome pathway revealed the causal involvement of oxidative stress in liver pathologies such as drug-induced liver injury, alcoholic liver disease, cholestatic liver injury, and nonalcoholic fatty liver disease (Kuijper et al
This effect generally resolves by reducing the dose or adjusting administration timing earlier in the evening
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Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase
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