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Free radical induced cellular inflammation appears to be a major contributing factor to cause aging, and degenerative diseases such as cancer, cardiovascular diseases, diabetes, hepatic diseases, renal ailments, and brain dysfunction

PDK4 (pyruvate dehydrogenase kinase 4) is known to switch glucose catabolism to fatty acid utilization 45

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fMRI data analyses All fMRI data were preprocessed and analyzed using readily available software packages: Analysis of Functional NeuroImages 115 , FMRIB Software Library 116 , Advanced Normalization Tools 117 , and Matlab (Mathworks, Natick, MA, USA)

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