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Thus, blockade of hepatic portal GLP-1R signaling causes glucose intolerance in rats, suggesting that GLP-1Rs located on nerve terminals in the hepatic portal vein contribute to the incretin action of GLP-1 (Vahl et al., 2007)

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Abbreviations AD: Alzheimers disease BBB: bloodbrain barrier GLP-1: glucagon-like peptide-1 GLP-1R(s): GLP-1 receptor(s) GLP-1RA(s): GLP-1 receptor agonists NDD: neurodegenerative diseases PD: Parkinsons disease T2DM: type 2 diabetes mellitus REFERENCES Knudsen LB, Lau J (2019) The Discovery and Development of Liraglutide and Semaglutide

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