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In research models, Tirzepatide simultaneously activates GLP-1 receptors (stimulating insulin secretion, suppressing glucagon, and reducing appetite) and GIP receptors (enhancing insulin secretion and modulating adipose tissue metabolism)

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If you dig into the research, we've got decades worth

Both medications carry a risk for rare but serious side effects, including pancreatitis and possible thyroid C-cell tumors (seen mainly in animal studies)