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The restraints were derived from (i) NOE restraints from intermolecular and intramolecular cross-peaks in NOESY spectra (described in NMR spectroscopy section), (ii) TALOS derived p53 TAD2 and FOXO4-DRI backbone dihedral angles, (iii) hydrogen bond restraints (regions p53 residues 4752, FOXO4-DRI residues 918

Creatine Creatine is best known for its role in muscle energy production, but research also has found it may support brain function and reduce age-related muscle loss (sarcopenia)

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When you lose weight, your body becomes more sensitive to insulin, which can improve blood sugar regulation

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