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7a, b, Cys 2 starvation as well as BSO and erastin treatment increased the percentage of cells in the G0/G1 phase with a concomitant decrease in the G2 phases, suggesting that GSH depletion induces growth arrest in RPE cells
However, growing evidences in the last two decades suggest that GPx2 and GPx4 may also influence the cellular radiosensitivity in an organ-specific manner (Table 2) [54,55,56, 67]
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Meister A: Glutathione deficiency produced by inhibition of its synthesis, and its reversal
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