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Yet, it is not known whether oral curcumin administration will result in breast tissue concentrations that are high enough to inhibit cancer chemotherapeutic agents in humans (11)

Future studies should focus on spatiotemporal dynamics, the dominant roles of different forms of RCD, and the identification of the key molecular switches that govern their interactions

Notwithstanding about the promising mechanisms of action, translation to patients is limited by bioavailability and pharmacokinetic issues, inter-subject variability and possible interactions with other chemotherapeutic agents or endocrine therapies highlighting the need for well-conducted randomised controlled trials and PKPD studies (248)

NAD+ helps drive cellular energy production by shuttling electrons in metabolic pathways like glycolysis and the Krebs cycle, ultimately enabling ATP synthesis for cell function

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