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Hansen et al., 2012)

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Side Effects and Safety: Similarities, Differences, and Red Flags Common Side Effects (Both) Typical side effects listed in labeling include: Nausea Vomiting Diarrhea or constipation Abdominal pain or discomfort Decreased appetite Practical tolerability tips many clinicians use (individualize to your care plan): Eat smaller meals and stop when comfortably full Prioritize protein and fiber Avoid large, high-fat meals during dose escalation Hydrate consistently, especially if nausea limits intake Boxed Warning and Key Contraindications (Both) Both products carry a boxed warning related to thyroid C-cell tumors in rodent studies and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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