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The effect of GLP-1R agonists on reversing amphetamine-induced locomotion and that liraglutide may act similar to lithium in terms of reversing cognitive deficits and liraglutide decreased lithium-induced weight gain brought the idea that GLP-1 analogs can serve as a potential target for psychostimulant abuse and treatment for bipolar disorder since it can reverse several aspects of mania and drug-induced side effects in bipolar disorder (Chaves Filho et al., Secondly, GLP-1 could have a significant role in psychological stress responses, in addition to mood disorders

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The possibility that incretin enhancer therapy could be neuroprotective is likely given that GLP-1 receptors are expressed in neurons from rodents and humans [88, 89] and that native GLP-1 and GLP-1 analogs readily cross the blood brain barrier [90, 91]