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People with Absorption Issues Several conditions can impair B12 absorption: Pernicious anaemia An autoimmune condition thats the most common cause of severe B12 deficiency in the UK Crohns disease or coeliac disease Previous gastric surgery Including gastric bypass Chronic use of certain medications Including proton pump inhibitors (PPIs), metformin, and some anti-seizure medications Others at Risk Pregnant and breastfeeding women (who have increased B12 requirements) Heavy alcohol consumers Those with chronic inflammation affecting gut health People taking certain oral contraceptives B12 Deficiency in the UK: How Common Is It

Other peptides under investigation Several additional peptides are being studied for disc-related applications, though with less established evidence: Vasoactive Intestinal Peptide (VIP) has demonstrated the ability to slow disc degeneration progression and improve aggrecan levels in mouse studies

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