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There is no scientific evidence for microdosing GLP-1s, Erlanger said
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A comparison of the two complexes (Tirzepatide bound to GLP-1R vs GIPR) shows that several of the same amino acids of the peptide interact with corresponding amino acids in the GLP-1 with GLP-1R
As it stands right now, it seems that Ozempic / semaglutide is more powerful than berberine as a GLP-1 agonist, while berberine (when dosed well enough) can compete with metformin in terms of glycemia and lipids
doi: 10.1007/978-1-4939-1203-2_7 26
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