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What the SELECT Trial Mediation Analysis Revealed The most definitive clinical evidence that cardiovascular protection is not driven by weight loss comes from a prespecified analysis of the SELECT trial, which enrolled 17,604 patients with obesity and established cardiovascular disease but no diabetes

Continuous real-time monitoring of blood pressure, pulse rate, and oxygen saturation (SpO2) by ACLS-certified ICU nursing staff throughout the entire duration of each infusion session

GLP-1 receptor agonists, including tirzepatide, are thought to exert neuroprotective effects through the modulation of neuroinflammation, the hypothalamic-pituitary-adrenal (HPA) axis, and neurotransmitter pathways, which play key roles in mood regulation and stress response ( The study has several strengths, including the use of a large, real-world database from the TriNetX network, which enhances the generalizability of our findings