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At therapeutic doses, the small amount of NAPQI produced is neutralized by conjugation with reduced glutathione (GSH), as shown in Figure 1, a crucial tripeptide that, in an NADPH-dependent reaction, helps detoxify oxidants like NAPQI
Maintenance sessions are necessary to sustain lighter skin tones
The pharmacokinetics also explain why blood levels rise gradually and reach steady state after ~45 weekly doses, at which point effects feel more consistent
Long-term results of deep brain stimulation of the anterior cingulate cortex for neuropathic pain
NG28 Initial medicines chapter
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