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The new US Administrations broader policy goals to rebalance prices between the US and rest of world brought new challenges in the UK: in September 2025, Eli Lilly implemented a UK-wide list price increase of up to 170% for Mounjaro paid for out-out-pocket, where the UK will be a 2bn+ market by the end of 2025
Gastrointestinal effects (nausea, diarrhea) are minimized with subcutaneous route
A post hoc meta-analysis used a predictive model to evaluate the cardiovascular risk of patients from all PIONEER and SUSTAIN clinical trials (n = 18 studies) [61]
Gueta, I
The Q4 data suggests that generic API is at the best starting point in 3 years for a potential re-rating but only if the pricing cycle cooperates
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