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They tended to be older and have a higher body mass index, higher rates of bariatric surgery and chronic hypertension, and present earlier for prenatal care

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A change in diabetes drug prescribing led to clinical trials of intranasal insulin administration, followed by insulin sensitizers, including metformin and peroxisome proliferator-activated receptor agonists, followed by incretin mimetics targeting primarily GLP-1R (GLP-1RAs) [106]

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