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Compared with those in the WT group, the expression levels of these five genes were lower in the control group ( P = 0.1413, 0.0098, 0.0006, 0.0007, and 0.3512 for Glp1r , Htr4 , Ntsr1 , Nos1 , and Ntrk1 , respectively), whereas the expression levels were significantly greater in the combination group than in the control group ( P = 0.0013, 0.0017, 0.0043, 0.0023, and 0.0016 for Glp1r , Htr4 , Ntsr1 , Nos1 , and Ntrk1 , respectively) (Fig

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An increasing number of studies have shown that HIF-1 can induce mitochondrial autophagy and inhibit mitochondrial biosynthesis to inhibit cell death, ultimately leading to HIF-1-mediated resistance