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Compared to other technologies, LC-MS/MS offers high specificity, selectivity, and a wide dynamic range, making it less susceptible to interference and applicable across various biological matrices
Approximately 90% of GLP-1 is metabolized by DPP-4 before reaching the central venous circulation (Holst and Deacon, 2005), and the peak circulating concentration of active GLP-1 (7-36)NH 2 after a meal in healthy subjects is usually less than 10 pmol/L due to the rapid degradation of DPP-4 (Bak et al., 2014)
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