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It is induced by mutations in the gene encoding 3-hydroxysterol- 7 -reductase (DHCR7), the enzyme catalyzing cholesterol formation by 7-dehydrocholesterol reduction
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Vitamin B12 or folate deficiency anaemia Complications
GlaxoSmithKline cited commercial reasons (poor market uptake compared to Trulicity and Ozempic)
In preclinical cell culture assays measuring dendritic arborization and synaptic outgrowth, Dihexa demonstrated neurotrophic activity estimated to be up to seven orders of magnitude 1,000,000 times more potent than Brain-Derived Neurotrophic Factor (BDNF) on a molar basis
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