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J Biol Eng
Importantly, as blood glucose levels dropped, so too did the ability of GLP-1 to stimulate further insulin releaselimiting the potential for dangerous hypoglycemia (drop in blood glucose)
In addition to suppressing hunger, this innovation enhances glucose tolerance and prevents weight gain, making it a promising option for managing obesity
HPG axis central effects: hypothalamus and pituitary Evidence on the potential neuroendocrine actions of GLP-1 on HPG axis was provided by an in vitro study in a rodent hypothalamic neuronal cell line (GT1-7) that reported a dose-dependent stimulating effect of GLP-1 on GnRH release, in association with a prompt increase in the plasma LH levels following the intracerebroventricular injection of GLP-1 in male rats [34]
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