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Both peptides promote collagen synthesis, but through different pathways, creating a more comprehensive collagen-building stimulus than either achieves alone

Gastrointestinal effects lead: nausea, diarrhea, constipation, and vomiting, dose-dependent and clustered during escalation, mostly mild. Tirzepatide also produces a modest chronic heart-rate rise with a larger escalation-phase peak. Oral-contraceptive absorption can fall after starting and after each increase, so use backup or non-oral contraception for 4 weeks each time. What is known about concurrent metformin and tirzepatide use

Flares can occur on the inner elbows during one episode and behind the knees or on the wrists during another