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You know, you get to a point where you're just like, okay, reward center is full and then it's off, you're done
In the Phase 2 trial, participants who started directly at 4 mg (without the 2 mg titration period) experienced nearly double the rate of gastrointestinal adverse events compared to those who started at 2 mg (Jastreboff et al., NEJM 2023)
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The CCI score was calculated after excluding mild and moderate-to-severe liver disease, as well as diabetes with chronic complications, which were treated as separate variables
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