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These effects were mediated by an increase in phosphorylation of mTOR and/or its downstream substrates, p70-S6 kinase (S6K) and the Eukaryotic translation initiation factor 4E-binding protein-1 (4E-BP1) [21]

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Surgical treatment Sun et al.44 tested 48 patients with chronic constipation and demonstrated that patients with MC are more suitable for ileosigmoidal anastomosis (ISA) than cecorectal anastomosis (CRA)

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