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Advancing GLP-1 therapeutics with analytical innovation The development of GLP-1-based drugs, which are used to treat type 2 diabetes and obesity, requires precise, high-sensitivity analytical techniques to navigate the complexity of peptide therapeutics

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We therefore suggest for future studies on monothiol mechanism (i) to take the bulkiness of the putative Grx(SSR) intermediate, an S N 2 reaction geometry, and a possible accumulation of Grx(SSR) as an artifact into account (Fig