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All melanocortin receptors are class A G-protein-coupled receptors signalling principally through Gs and adenylyl cyclase to raise intracellular cAMP, and MC4R is the subtype whose ligand-bound active-state architecture is best resolved, including a 2021 cryo-EM series that captured bremelanotide bound to full-length MC4R in complex with heterotrimeric Gs
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G (00:15:20):Were going to get to some people you know I think
57 MazzaM
The replies are more individualized than the boilerplate-only responses we see at lower-graded clinics, but the templated opener stands out
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