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A meta-analysis found that the use of GLP-1 agonists was associated with an increased risk of overall thyroid disorders, although no significant effects were observed on specific conditions such as hyperthyroidism or hypothyroidism

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Albiglutide (GlaxoSmithKline) is a fusion of two GLP-1 molecules with human albumin, which increases the proteolytic stability of GLP-1 and slows renal clearance, extending the half-life to 120 h

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