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When two compounds share a final therapeutic outcome (tissue repair) but achieve it through different receptors and cellular intermediaries, their combination can produce effects that exceed what either compound delivers alone without requiring dose escalation of either component
Wong JHC, Ma JYW, Jobling AI, et al
First comes inflammation , with platelet activation and release of growth factors
The BA concentration in samples were quantified by using ultra-fast liquid chromatography (UFLC)-Triple-time of flight/mass spectrometer 44,45
Together, these data demonstrate that liraglutide treatment increases bihormonal insulin + glucagon + cells at the islet periphery in a cell GLP-1Rdependent fashion
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