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Instead, they act as ATP-independent holdases that bind misfolded or partially unfolded proteins, preventing their aberrant aggregation and facilitating subsequent degradation
Contrastly, tirzepatide does not have significant data around this yet and will require additional monitoring of oral medications, especially those with narrow therapeutic indices or that are concentration-dependent
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It is also approved to reduce the risk of major cardiovascular events like heart attack, stroke, or death in adults with type 2 diabetes with known heart disease
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