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Since Melanogenesis causes the production of skin pigment, its inhibition results in an overall skin whitening
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Primary amines also allow installation of pH-sensitive (e.g., imine, hydrazone) or redox-sensitive (e.g., disulfide) linkages that remain stable in blood but cleave in the acidic, reducing TME triggering payload release precisely where it is needed
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Liraglutide also induction HO-1 expression by activating AMPK and promoting HIF-1 protein export from cytoplasm to nucleus, which significantly increases the expression of anti-apoptotic protein Bcl-2 and decreases the expression of pro-apoptotic Bax and Caspase-3 in HUVECs cells [134]
