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The stress of the disease and its potential complications was stated to be emotionally taxing for respondents, negatively influencing social interactions, mental health, and, ultimately, overall quality of life of patients

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The GSH antioxidant system serves as the primary endogenous defense mechanism against oxidative stress, playing a direct and active role in neutralizing ROS and maintaining the reduced (active) forms of vitamins C and E, which are essential for cellular function and protection []

Importantly, we then critically evaluate how advanced delivery systemsparticularly biomimetic, stimuli-responsive, and bone-targeted nanocarriersare rationally engineered to dismantle these exact barriers