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Our research indicated that by detecting the levels of ATF4, GPX4, GSS, KEAP1, and ATG3 in the peripheral blood of patients with ovarian cancer, their progression and prognosis could be rapidly, accurately, and effectively predicted, and their sensitivity to adjuvant therapy with ferroptosis-related drugs could be predicted
It plays a critical role in detoxifying hydroxide peroxide (H2O2)
Additionally, loss-of-function mutations in the TP53BP1 gene result in decreased 53BP1 protein expression and facilitate BRCA1-independent DNA end resection, which accounts for platinum and PARPi resistance [58]
Pant et al., 2023
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