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Matrixyl (Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7) Compatibility: Excellent
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Other notable effects include cholelithiasis (1.6% vs 0.7% placebo in STEP 1, related to rapid weight loss), a diabetic retinopathy signal in SUSTAIN-6 (HR 1.76, attributed to rapid HbA1c improvement), and a modest increase in resting heart rate of 2-4 bpm
However, the landmark SURMOUNT-5 trial (published in mid-2025), which compared the two medications head-to-head, clarified the clinical reality: Total Weight Loss: Tirzepatide drives significantly greater total weight loss (averaging over 20%) compared to semaglutide (averaging roughly 14%)
Whilst Wegovy is effective for weight reduction when used alongside lifestyle changes, some patients wonder whether it might affect libido or sexual function
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