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Possible mild side effects include injection site irritation, headaches, or flushing
Studies on tirzepatide also indicate promising effects on cardiovascular risk markers and blood pressure, with ongoing trials further evaluating its direct impact on cardiovascular outcomes [Ludvik et al., 2021]
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Retatrutide (a triple GIP/GLP-1/glucagon receptor agonist), survodutide, mazdutide, and CagriSema represent the next generation of anti-obesity compounds that may offer even greater efficacy or better tolerability profiles
Sattar N, Neeland IJ, Dahlqvist Leinhard O, Fernndez Land L, Bray R, Linge J, Rodriguez A (2025) Tirzepatide and muscle composition changes in people with type 2 diabetes (SURPASS-3 MRI): a post-hoc analysis of a randomised, open-label, parallel-group, phase 3 trial
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