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Normalized counts were obtained through variance stabilizing transformation (VST)
By activating GLP-1 receptors, tirzepatide enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriate glucagon release, slows gastric emptying, and reduces appetite through central nervous system pathways
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Its use is limited by a broad side-effect profile, including anticholinergic effects (e.g., dry mouth, urinary retention), sedation, and orthostatic hypotension
arXiv preprint arXiv:1208.5347.
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