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Published 2014 Nov 19
The distinct mode of CTR and AMYR engagement by Cagri revealed in the current study, together with the correlated distinctions in functional responses at individual receptors, is likely to be important in the differentiated, high efficacy, of Cagri as a first-in-class obesity drug in both preclinical animal models and in treatment of obese patients in clinical trials 2,3,4
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4 An important note on interpretation: These are observational associations, and thoughtful critics have pointed out that some of the circulating xylitol and erythritol in these cohorts may reflect the body's own internal production during metabolic stress rather than what people ate
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