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Each shows the exact mistake, the measurable consequence, and the fix

By recognizing the DAMPs, this receptor activates the inflammasome, which, through the caspase-1 pathway, induces the processing of pro-IL1 into active IL1, as well as its secretion into the extracellular environment, where it perpetuates the inflammatory response.75 IL1 plays a key role in the polarization of T cells towards Th17.76 The perilesional skin of vitiligo, where the disease is most active, shows an increase in IL1, suggesting that this pathway is also involved in vitiligo progression.77 Therefore, IL1 inhibition can also be seen as a potential therapeutic target in vitiligo

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The intravenous formulation (fosgonimeton) was designed to circumvent this, but the results suggest it still failed to achieve sufficient brain levels or duration of action