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In the present study, DCFH fluorescence levels were consistently higher in the VPA group compared to the CT group in the cerebellum, hippocampus, posterior cortex, and striatum, indicating increased oxidative stress and supporting the effectiveness of the VPA-induced animal model
For example, deficiencies in vitamins B6, B12, and folate can impair methylation processes, as these vitamins are required for the production of SAMe, a key methyl donor
The New England Journal of Medicine, 389(6), 514526
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However, the complexity of balancing three different receptor pathways creates new challenges for dose optimization and safety management
