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Semaglutide and tirzepatide are at the forefront of this new era in chronic weight management, offering hope to patients who have struggled to achieve their goals through traditional means alone
Nevertheless, it is noteworthy that, in the HARMONY 7 trial 10 which was a head-to-head comparison between liraglutide and albiglutide (but which was not powered for cardiovascular outcomes), the fall in HbA1c for liraglutide was 0.98% compared with 0.79% for albiglutide (p=0.085) whereas the weight decrease was 2.2 kg for liraglutide compared with 0.6 kg for albiglutide (p0.0001)
It also means recognising that the maintenance dosage may change over time in either direction
The addition of 99445 allows providers to receive reimbursement when patients fall short of that threshold or do not benefit from more than 16 days of device transmission
however, there was no significant difference between the different groups when compared to vehicle dosed animals
