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On the other hand, acute-on-chronic liver failure is characterized by intense systemic inflammation, a close temporal relation to a precipitating event, and the presence of one or multiple organ failures
doi: 10.1016/j.chest.2020.07.023 48 CuadradoA.PajaresM.BenitoC.Jimnez-VillegasJ.EscollM.Fernndez-Ginset al
It was originally isolated from the blood of rabbits that had been induced into slow-wave (delta) sleep, which is how it got its name
Activated mast cells can trigger microglial activation via the release of histamine, prostaglandins, and protease-activated receptor ligands (Zhang et al., 2016)