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By modulating electrostatic interactions between charged peptide drugs and the polymer matrix, these hydrogels enable sustained and steady drug elution over extended periods, ranging from days to weeks, significantly reducing dosing frequency from daily to weekly or even monthly intervals [46]
Of particular interest in the present study is that AMPK activation appears to be, at least partially, redox-associated
NAC should be given relatively quickly after an overdose, as its efficacy begins to decline 8-10 hours following intoxication (Smilkstein 1988