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Possible side effects associated with long-term use (12-24 months) have yet to be established in clinical research studies

In general, ROS signaling in eryptosis is less diverse compared to nucleated cells, since in erythrocytes, ROS mainly mediate PS externalization by modulating Ca 2+ influx, while in nucleated cells, there are multiple signaling pathways downstream of ROS involved in the execution of apoptosis

This is my only theory

There are several health benefits of B12 shots that people are not aware of

Long-term use of metformin (for type 2 diabetes) or proton pump inhibitors can also deplete B12 levels over time