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Subsequent studies have found that the mineral selenium is essential for GPX1 activity (Seale et al., 2020)
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A phase II study result showed that administering a high dose of survodutide, up to 1.8 mg twice weekly, resulted in over 50% of T2D participants achieving more than 5% body weight reduction, and over 25% experiencing a weight loss exceeding 10% [111]
In addition, the iron-containing metal-organic framework TPL@TFBF is formed through the coordination of tannic acid (TA) with Fe + , loaded with triptolide (TPL) and coated with FA-modified BSA, among them TPL increases intracellular ROS production by inhibiting the expression of Nrf2, leading to ferroptosis and pyroptosis, releasing a large amount of DAMPs, which in turn stimulates DCs antigen presentation and CD4 + /CD8 + T cell proliferation thereby suppressing tumor growth and metastasis (227)
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