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If you experience no appetite changes after four to six weeks of escalating doses, discuss with your provider whether the medication is working as expected
Yang X, Qiang Q, Li N, Feng P, Wei W, Hlscher C
SURPASS-2 showed tirzepatide was superior to semaglutide 1mg for both A1C reduction (2.09% vs 1.86%) and weight loss (12.4% vs 6.2%) at the 15mg dose, establishing the clinical relevance of dual-agonism over selective GLP-1 agonism
Obesity trials use weight as the primary endpoint
Since the brain has GLP-1 receptors, these drugs can influence brain functions beyond metabolism, including mood regulation and cognitive processes
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