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That means the first weeks may be more about reaching tolerability than reaching maximum effect

If youve been on semaglutide for a month and still feel persistently hungry, its important to address this with your provider and youre not alone

& Busciglio, J

Why Retatrutide May Show More Reward Blunting in Some Research Subjects The most plausible explanation lies in signal stacking : GLP-1 reduces hedonic and reward-driven feeding GIP modulates metabolic and central signaling Glucagon increases energy expenditure and output-oriented physiology Together, these signals may: Further suppress reward-seeking behaviors Reduce the relative salience of pleasure-based stimuli Shift behavioral and metabolic priorities toward efficiency and fuel utilization In some nervous systems, this tradeoff may be observed as reduced reward responsiveness or anhedonia-like features

This is more likely to happen in people who are sensitive to changes in their blood sugar or who are also taking other medications that lower blood sugar