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The waiting period for tirzepatide is somewhat shorter than for semaglutide (6 to 8 weeks versus 8 to 10 weeks) due to tirzepatides faster clearance

Background Semaglutide belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists

Patients over 65 years require particular attention to muscle preservation, as excessive lean mass loss can impair functional independence and increase fall risk

A large real-world study of 18,000 patients found tirzepatide patients were roughly twice as likely to achieve 10% or more weight loss

Taste changes and food aversions occasionally persist but rarely prevent continued use